FPS-ZM1, CAS [[945714-67-0]]

Product Overview

• Article Name: FPS-ZM1, CAS [[945714-67-0]]
• Biozol Catalog Number: FBM-10-4616
• Supplier Catalog Number: 10-4616
• Alternative Catalog Number: FBM-10-4616-10MG, FBM-10-4616-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide

Product Description

RAGE inhibitor

Product Properties

• Molecular Weight: 327.85
• Purity: 98% by HPLC, NMR (Conforms)
• Form: Off-White solid
• CAS Number: [945714-67-0]
• Formula: C20H22ClNO

Application Notes

• Application Notes: FPS-ZM1 is a high-affinity Receptor for Advanced Glycation End products (RAGE) inhibitor (IC50 = 0.6 µM). It is able to lower levels of Abeta via binding to the V domain of RAGE and can block multiple mechanisms of Abeta40- and Abeta42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo.1,2 Can cross the BBB. In a rat model of intracerebral hemorrhage, FPS-ZM1 was able to attenuate blood-brain barrier and white matter fiber damage.3 FPS-ZM1 inhibition of RAGE was able to ameliorate inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1(HMGB1) signaling.4 FPS-ZM1 has also been shown to impair breast cancer cell invasion and metastasis.5