TH1760, CAS [[2567914-01-4]]

Product Overview

• Article Name: TH1760, CAS [[2567914-01-4]]
• Biozol Catalog Number: FBM-10-4624
• Supplier Catalog Number: 10-4624
• Alternative Catalog Number: FBM-10-4624-5MG, FBM-10-4624-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-[4-(1H-Indole-5-carbonyl)piperazin-1-yl]sulfonyl-3H-1,3-benzoxazol-2-one

Product Description

NUDT15 inhibitor

Product Properties

• Molecular Weight: 426.45
• Purity: 98% by TLC, NMR (Conforms)
• Form: Off-white solid
• CAS Number: [2567914-01-4]
• Formula: C20H18N4O5S

Application Notes

• Application Notes: Potent inhibitor (IC50 = 25 nM dGTP hydrolysis, 57 nM 6-thio-dGTP hydrolysis) of the NUDIX hydrolase NUDT15, an important enzyme involved in the hydrolysis thiopurine chemotherapeutics. It was selective against other human NUDIX proteins as well as a panel of 44 kinases and the Eurofins Cerep SafetyScreen44 panel. It was active in AML cell lines HL-60 and NB4 as well as HCT116 3-6 colorectal carcinoma cells and 697 B-ALL cells.