Chemical Name: (2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate. Alternate Names: Tavist
Histamine H1 receptor antagonist
Molecular Weight:
459.96
Purity:
>98% by TLC NMR (Conforms)
Form:
White solid
CAS Number:
[14976-57-9]
Formula:
C21H26ClNOC4H4O4
Application Notes:
Histamine H1 antagonist with anti-muscarinic effects at the M1 receptor. Enhances remyelination in a mouse model of demyelination.1 Displays protective role against neuroinflammation and demyelination via anti-inflammatory and anti-pyroptotic actions.2 Clemastine promoted oligodendrocyte differentiation in a rat model of spinal cord injury via muscarinic receptor mediated activation of ERK1/2 signaling.3
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