AMPK activator/Mitochondrial protein complex I inhibitor
Molecular Weight:
315.30
Purity:
>98% by HPLC NMR (Conforms)
Form:
White solid
CAS Number:
[1422365-93-2]
Formula:
C13H16F3N5O
Application Notes:
Potent activator of AMP-activated protein kinase (AMPK) showing greater activity than metformin or AICAR.1 It displayed protective effects in vivo against peritoneal1, liver2, renal3,and pulmonary fibrosis4. IM156 induces metabolic stress in Myc+ lymphoma cells by inhibiting TCA cycle metabolism and mitochondrial respiration (inhibits mitochondrial protein complex 1).4 IM156 acts as an antiproliferative in several cancer models.5-7
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