ML365, CAS [[947914-18-3]]

Product Overview

• Article Name: ML365, CAS [[947914-18-3]]
• Biozol Catalog Number: FBM-10-4658
• Supplier Catalog Number: 10-4658
• Alternative Catalog Number: FBM-10-4658-5MG,FBM-10-4658-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Potent and selective K2P3.1 blocker

Product Properties

• Molecular Weight: 360.41
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [947914-18-3]
• Formula: C22H20N2O3

Application Notes

• Application Notes: ML365 is a potent (IC50 = 16 nM) and selective (62-fold selective over TASK-3) blocker of the two-pore domain potassium channel K2P3.1 (TASK-1) .1 It also less potently (IC50 = 4.07 µM) blocks the K2P6.1 (TWIK-2) channel resulting in blocking the ATP-induced NLRP3 inflammasome.2 ML365 improved the efficacy of Levetiracetam in chronically epileptic rats.3 It suppressed the release of TNF-alpha, IL-6, and IL-1ß in an LPS-induced inflammatory model via regulation of NF-kB signaling.4