AZ20, CAS [[1233339-22-4]]

Product Overview

• Article Name: AZ20, CAS [[1233339-22-4]]
• Biozol Catalog Number: FBM-10-4675
• Supplier Catalog Number: 10-4675
• Alternative Catalog Number: FBM-10-4675-5MG, FBM-10-4675-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-{4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl}-1H-indole

Product Description

ATR Kinase inhibitor

Product Properties

• Molecular Weight: 412.51
• Purity: 98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1233339-22-4]
• Formula: C21H24N4O3S

Application Notes

• Application Notes: AZ20 is a potent and highly selective inhibitor of Ataxia telangiectasia mutated and RAD3-related (ATR) kinase (IC50 = 5 nM in vitro, IC50 = 50 nM in HT29 colorectal adenocarcinoma cells).1 Combination therapy with AZ20 and gemcitabine resulted in synergistic inhibition of tumor cell growth and cell death initiation in pancreatic cancer cell lines.2