Chemical Name: 4-[3-Cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine 2HCl
Casein kinase 1delta/epsilon inhibitor
Molecular Weight:
337.40
Purity:
>98% by HPLC, NMR (Conforms)
Form:
Off-white solid
CAS Number:
[950912-80-8]
Formula:
C19H22Cl2FN5
Application Notes:
Potent inhibitor of casein kinase 1epsilon/delta (CK1epsilon, IC50 = 7.7 nM, CK1delta, IC50 = 14 nM).1 It is a circadian clock modifier that caused robust phase delays in rats1 and Cynomolgus monkeys2. PF-670462 caused nuclear retention of the clock protein PER resulting in period lengthening in a phase-specific manner that was dependent on CK1delta inhibition and not CK1epsilon.3 It improved cognitive performance and reduced amyloid load in various mouse models of Alzheimers disease.4-6 PF-670462 slowed the progression of and increased survival of chronic lymphocytic leukemia in mice alone and in combination with Ibrutinib.7
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