Chemical Name: 3-[4-[[1-(Cyclopropanecarbonyl)-3,4-dihydro-2H-quinolin-7-yl]sulfamoyl]phenyl]benzamide
OGG1 inhibitor
Molecular Weight:
475.56
Purity:
98% by HPLC, NMR (Conforms)
Form:
Off-white solid
CAS Number:
[2210228-45-6]
Formula:
C26H25N3O4S
Application Notes:
Potent (IC50 = 59 nM) inhibitor of the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1).1,2 Selective versus other DNA repair enzymes (MTH1, DUT, NUDT16, ABH2, ABH3, and SMUG1). SU0268 inhibited proinflammatory responses to Pseudomonas aeruginosa infection in C57BL/6 wild-type mice.3
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