Perphenazine is a clinically useful typical antipsychotic drug. The therapeutic mode of action is not well understood but it binds to a wide variety of receptors including serotonin, histamine, dopamine, and alpha-adrenergic.1 Perphenazine is an inhibitor of acid sphingomyelinase(ASM)2 and positively effected xenografted tumor growth via perturbation of intracellular cholesterol transport through ASM3. It has also been shown to be an inhibitor of glutamate dehydrogenase.4
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