Chemical Name: N-[4-(1H-Benzoimidazol-2-yl)-phenyl]-succinamic acid
Mitochondrial GPDH inhibitor
Molecular Weight:
309.32
Purity:
98% by TLC NMR (Conforms)
Form:
Beige solid
CAS Number:
[27031-00-1]
Formula:
C17H15N3O3
Application Notes:
A potent and cell permeable inhibitor of the mitochondrial glycerol-3-phosphate dehydrogenase (mGPDH), IC50=6.3 M, which is selective over the cytosolic enzyme1. It does not block pyruvate uptake into cells or mitochondria and has no direct effect on glycolysis in synaptosomes. This novel inhibitor is a unique tool which may be used to investigate the role of glycerol-3-phosphate metabolism in isolated and intact systems.1
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