Deucravacitinib, CAS [[1609392-27-9]]

Product Overview

• Article Name: Deucravacitinib, CAS [[1609392-27-9]]
• Biozol Catalog Number: FBM-10-4756
• Supplier Catalog Number: 10-4756
• Alternative Catalog Number: FBM-10-4756-5MG, FBM-10-4756-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-(Cyclopropanecarbonylamino)-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide. Alternate Names: BMS-986165

Product Description

Allosteric TYK2 inhibitor

Product Properties

• Molecular Weight: 425.47
• Purity: 98% by HPLC NMR (Conforms)
• Form: White or off-white solid
• CAS Number: [1609392-27-9]
• Formula: C20H19D3N8O3

Application Notes

• Application Notes: Deucravacitinib is very potent and selective allosteric inhibitor of tyrosine kinase 2 (TYK2). It binds to and is selective for the TYK2 pseudokinase domain (JH2, IC50 = 0.2 nM), with no activity against canonical JH1 domain of TYK2, JAK1,2, or 3.1 It is 5-fold less active against the JAK1 JH2 domain (IC50 = 1 nM). Deucravacitinib blocked signaling and functional responses in human TH17, TH1, B cells, and myeloid cells and displayed robust efficacy in vitro and in vivo in autoimmune disease animal models.2