Ibrutinib, CAS [[936563-96-1]]

Product Overview

• Article Name: Ibrutinib, CAS [[936563-96-1]]
• Biozol Catalog Number: FBM-10-4757
• Supplier Catalog Number: 10-4757
• Alternative Catalog Number: FBM-10-4757-10MG, FBM-10-4757-50MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one. Alternate Names: PCI-32765

Product Description

BTK inhibitor

Product Properties

• Molecular Weight: 440.51
• Purity: 99% by HPLC NMR (Conforms)
• Form: White or off-white solid
• CAS Number: [936563-96-1]
• Formula: C25H24N6O2

Application Notes

• Application Notes: Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).1 Ibrutinib also potently inhibits several other kinases including BLK, BMS, FGR, EGFR, and ITK. It is a clinically useful drug to treat B cell cancers. It inhibits CLL cell migration and survival2,3 and downregulates expression of CD204. It enhanced antitumor immune responses in combination with anti PD-L1 blockade via its inhibition of ITK (IL2-inducible T-cell kinase).5