AZ3146, CAS [[1124329-14-1]]

Product Overview

• Article Name: AZ3146, CAS [[1124329-14-1]]
• Biozol Catalog Number: FBM-10-4778
• Supplier Catalog Number: 10-4778
• Alternative Catalog Number: FBM-10-4778-5MG,FBM-10-4778-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

Msp1 kinase inhibitor

Product Properties

• Molecular Weight: 452.56
• Purity: 98% by HPLC NMR (conforms)
• Form: Off-white solid
• CAS Number: [1124329-14-1]
• Formula: C24H32N6O3S2

Application Notes

• Application Notes: AZ3146 is a potent (IC50 = 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1 Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2