Fruquintinib, CAS [[1194506-26-7]]

Product Overview

• Article Name: Fruquintinib, CAS [[1194506-26-7]]
• Biozol Catalog Number: FBM-10-4784
• Supplier Catalog Number: 10-4784
• Alternative Catalog Number: FBM-10-4784-5MG, FBM-10-4784-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 6-(6,7-Dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide. Alternate Names: HMPL-013

Product Description

VEGFR kinase inhibitor

Product Properties

• Molecular Weight: 393.40
• Purity: 98% by HPLC NMR (Conforms)
• Form: White soliod
• CAS Number: [1194506-26-7]
• Formula: C21H19N3O4

Application Notes

• Application Notes: Fruquintinib is a potent and highly selective inhibitor of VEGFR kinase (IC50s: VEGFR1= 33 nM, VEGFR2 = 35 nM, VEGFR3 = 0.5 nM).1 It potently inhibited VEGF/VEGFR signaling and cell proliferation in HUVECs and HLECs and prevented angiogenesis in vitro. Fruquintinib is currently is several clinical trials against metastatic colorectal cancer2 and nonsquamous non-small-cell lung cancer3.