Larotrectinib, CAS [[1223403-58-4]]

Product Overview

• Article Name: Larotrectinib, CAS [[1223403-58-4]]
• Biozol Catalog Number: FBM-10-4832
• Supplier Catalog Number: 10-4832
• Alternative Catalog Number: FBM-10-4832-5MG, FBM-10-4832-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (3S)-N-[5-[(2R)-2-(2,5-Difluorophenyl)pyrrolidine-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxypyrrolidine-1-carboxamide. Alternate Names: LOXO-101, ARRY-470

Product Description

panTRK inhibitor

Product Properties

• Molecular Weight: 428.44
• Purity: 98% by HPLC NMR (Conforms)
• Form: Yellow solid
• CAS Number: [1223403-58-4]
• Formula: C21H22F2N6O2

Application Notes

• Application Notes: Larotrectinib is a potent (IC50s < 11 nM) inhibitor of tropomyosin receptor kinases A, B, and C (TrkA, B, and C).1 It is >100 fold selective against a panel of 229 kinases. Larotrectinib markedly attenuated bone cancer pain and significantly blocked the formation of neuroma-like structures and the sprouting of sensory nerve fibers. Larotrectinib caused substantial tumor regression in various cancers displaying TRK gene fusions.2-4 Larotrectinib is the first tissue agnostic drug approved by the FDA.