NDI-091143, CAS [[2375840-87-0]]

Product Overview

• Article Name: NDI-091143, CAS [[2375840-87-0]]
• Biozol Catalog Number: FBM-10-4841
• Supplier Catalog Number: 10-4841
• Alternative Catalog Number: FBM-10-4841-5MG, FBM-10-4841-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: Methyl 3-Chloro-5-[(2,4-difluoro-5-phenylphenyl)sulfamoyl]-4-hydroxybenzoate

Product Description

Potent allosteric ATP-citrate lyase inhibitor

Product Properties

• Molecular Weight: 453.84
• Purity: >98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [2375840-87-0]
• Formula: C20H14ClF2NO5S

Application Notes

• Application Notes: Potent (IC50 = 2.1 nM ADP-Glo assay, 4.8 nM Oxaloacetate coupled enzyme assay) allosteric inhibitor of ATP-citrate lyase.1 NDI-091143 suppressed growth and clonogenic ability in thyroid cancer cell lines FTC-133 and 8505C.2 It also synergistically potentiated the cytotoxicity of sorafenib.2