UZH2, CAS [[2756566-45-5]]

Product Overview

• Article Name: UZH2, CAS [[2756566-45-5]]
• Biozol Catalog Number: FBM-10-4849
• Supplier Catalog Number: 10-4849
• Alternative Catalog Number: FBM-10-4849-5MG, FBM-10-4849-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-[4-[(4,4-Dimethylpiperidin-1-yl)methyl]-2,5-difluorophenyl]-9-[6-(methylamino)pyrimidin-4-yl]-1,4,9-triazasprio[5.5]undecane-2-one

Product Description

METTL3 inhibitor

Product Properties

• Molecular Weight: 513.64
• Purity: >98% by HPLC NMR (Conforms)
• Form: White or off-white solid
• CAS Number: [2756566-45-5]
• Formula: C27H37F2N7O

Application Notes

• Application Notes: UZH2 (2756566-45-5) is a potent (IC50 = 5 nM) and selective (against METTL1 and METTL16) inhibitor of the RNA methyltransferase METTL3, a key component of the writer complex targeting N6-methyladenosine (m6A), the most common RNA modification. It was able to impair cell growth (GI50 = 12 µM) in MOLM-13 cancer cells (AML).