LY2090314, CAS [[603288-22-8]]

Product Overview

• Article Name: LY2090314, CAS [[603288-22-8]]
• Biozol Catalog Number: FBM-10-4854
• Supplier Catalog Number: 10-4854
• Alternative Catalog Number: FBM-10-4854-5MG, FBM-10-4854-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-[6-Fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraene-3-yl]-4-imidazo[1,2-a]pyridine-3-ylpyrrole-2,5-dione. Alternate Names: 3-(9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6.7.1-hi]indol-7-yl)-4-(imidazo[1.2-a]pyridine-3-yl)-1H-pyrrole-2,5-dione

Product Description

Wnt/ß-Catenin pathway activator / GSK-3 inhibitor

Product Properties

• Molecular Weight: 512.54
• Purity: >98% by HPLC NMR (Conforms)
• Form: Orange solid
• CAS Number: [603288-22-8]
• Formula: C28H25FN6O3

Application Notes

• Application Notes: Wnt/ß-catenin pathway activator. LY2090314 is a highly potent (IC50 = 1.5 nM GSK-3alpha, 0.9 nM GSK-3ß) and selective inhibitor of glycogen synthase-3-kinase (GSK-3).1,2 It stabilized ß-catenin levels and elevated expression of Axin2 leading to tumor growth delays in A375 melanoma xenografts.2 LY2090314 significantly reduced growth in multiple neuroblastoma cell lines.3 It inhibited growth and induced apoptosis in osimertinib-resistant lung cancer cells, specifically those with a mesenchymal phenotype.4