NVP-2, CAS [[1263373-43-8]]

Product Overview

• Article Name: NVP-2, CAS [[1263373-43-8]]
• Biozol Catalog Number: FBM-10-4858
• Supplier Catalog Number: 10-4858
• Alternative Catalog Number: FBM-10-4858-5MG, FBM-10-4858-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 4-[[[6-[5-Chloro-2-[[4-[[(2R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]pyridin-4-yl]pyridin-2-yl]amino]methyl]oxane-4-carbonitrile

Product Description

CDK9 inhibitor

Product Properties

• Molecular Weight: 513.08
• Purity: >98% by HPLC NMR (Conforms)
• Form: Off-white to beige solid
• CAS Number: [1263373-43-8]
• Formula: C27H37ClN6O2

Application Notes

• Application Notes: NVP-2 is a highly selective and potent (IC50 = 0.514 nM) inhibitor of cyclin dependent kinase 9 (CDK9).1 It inhibited proliferation of MOLT4 cells (IC50 = 9 nM). Treatment of cells with NVP-2 resulted in profound downregulation of core regulatory circuitry genes. It has also been shown to be a potent inhibitor of CDK10 (IC50 = 29 nM, this study gives an IC50 of 6 nM for CDK9).2 NVP-2 acted synergistically with orlistat to inhibit acute myeloid leukemia cells (IC50s: Kasumi-1 cells 7.58 nM, U937 cells 8.99 nM).3