MLi-2 is a potent (IC50 = 0.76 nM) inhibitor of leucine-rich repeat kinase 2 (LRRK2).1,2 It has greater than 295-fold selectivity against a panel of 300 kinases. CNS active. An important tool for the study of aberrant LRRK2 signaling in Parkinsons disease.3-6
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