Chemical Name: cis-2,6-Dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1H-indazol-3-yl]pyrimidin-4-yl]morpholine
LRRK2 inhibitor
Molecular Weight:
379.46
Purity:
>98% by HPLC NMR (Conforms)
Form:
White or off-white solid
CAS Number:
[1627091-47-7]
Formula:
C21H25N5O2
Application Notes:
MLi-2 is a potent (IC50 = 0.76 nM) inhibitor of leucine-rich repeat kinase 2 (LRRK2).1,2 It has greater than 295-fold selectivity against a panel of 300 kinases. CNS active. An important tool for the study of aberrant LRRK2 signaling in Parkinsons disease.3-6
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