TASIN-1, CAS [[1678515-13-3]]

Product Overview

• Article Name: TASIN-1, CAS [[1678515-13-3]]
• Biozol Catalog Number: FBM-10-4890
• Supplier Catalog Number: 10-4890
• Alternative Catalog Number: FBM-10-4890-5MG, FBM-10-4890-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-[1-(4-Methoxyphenyl)sulfonylpiperidin-4-yl]-4-methylpiperidine hydrochloride

Product Description

Selectively induces apoptosis in cells with APC truncations

Product Properties

• Molecular Weight: 388.95
• Purity: 98% by HPLC NMR (Conforms)
• Form: White or off-white solid
• CAS Number: [1678515-13-3]
• Formula: C18H28N2O3SHCl

Application Notes

• Application Notes: Selectively induces apoptosis in cells with truncations in the adenomatous polyposis coli (APC) gene (but not normal cells or wild type cancer cells), an important multifunctional tumor suppressor gene.1 IC50 = 70nM for DLD1 cell line. It inhibited cancer cell growth in human tumor xenografts (DLD1 and HT29 tumors) and a genetically engineered mouse model (CPC,Apc) of colorectal cancer. TASIN-1 induces ER stress-dependent JNK activation with ROS production and AKT inhibition via cholesterol depletion.2