AX-024, CAS [[1704801-24-0]]

Product Overview

• Article Name: AX-024, CAS [[1704801-24-0]]
• Biozol Catalog Number: FBM-10-4895
• Supplier Catalog Number: 10-4895
• Alternative Catalog Number: FBM-10-4895-5MG, FBM-10-4895-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1-[[4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl]methyl]pyrrolidine hydrochloride

Product Description

T cell antigen receptor (TCR)-dependent T cell activation inhibitor

Product Properties

• Molecular Weight: 375.86
• Purity: 98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1704801-24-0]
• Formula: C21H22FNO2HCl

Application Notes

• Application Notes: AX-024 is a potent (IC50 ~ 1 nM) and specific inhibitor of T cell antigen receptor (TCR)-dependent T cell activation. It inhibited neither B cell proliferation triggered by B cell antigen receptor (BCR), TLR4, CD40 agonists nor IL-2-dependent proliferation of T lymphoblasts. AX-024 binds to the SH3.1 domain of the adaptor protein Nck blocking its interaction with the CD3 subunit on the T cell antigen receptor. AX-024 displayed protective effects in mouse models of psoriasis, allergic asthma, and multiple sclerosis. Importantly, the therapeutic effect of AX-024 persisted after removal of the drug in contrast to fingolimod suggesting a persistent modification of autoimmune T cells. Currently in clinical trials.