BAY 87-2243, CAS [[1227158-85-1]]

Product Overview

• Article Name: BAY 87-2243, CAS [[1227158-85-1]]
• Biozol Catalog Number: FBM-10-4910
• Supplier Catalog Number: 10-4910
• Alternative Catalog Number: FBM-10-4910-5MG, FBM-10-4910-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 5-[1-[[2-(4-Cyclopropylpiperazin-1-yl)pyridin-4-yl]methyl]-5-methylpyrazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

Product Description

HIF-1 / Mitochondrial complex I inhibitor

Product Properties

• Molecular Weight: 525.54
• Purity: 98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1227158-85-1]
• Formula: C26H26F3N7O2

Application Notes

• Application Notes: BAY 87-2243 potently inhibits HIF-1 reporter gene activity (IC50 = 0.7 nM) and CA9 protein expression (IC50 = 2.0 nM).1 It inhibited HIF-1 and HIF-2 protein accumulation in hypoxic H460 cells and reduced tumor weight in nude mice inoculated with H460 cells. BAY 87-2243 potently inhibits mitochondrial complex I activity (IC50 = 10 nM in mitochondria isolated from PC3 cells) leading to its HIF-1 effects. It has no effect on mitochondrial complex III. BAY 87-2243 reduced melanoma tumor growth via its targeting of mitochondrial complex I.2,3