Chemical Name: (R)-3-Phenyl-2-(3-(pyridine-3-ylmethoxy)benzamido)propanoic acid. Alternate Names: (2R)-3-Phenyl-2-[[3-(pyridine-3-ylmethoxy)benzoyl]amino]propanoic acid
G2A agonist
Molecular Weight:
376.14
Purity:
98% by HPLC NMR (Conforms)
Form:
Off-white solid
CAS Number:
[1608784-68-4]
Formula:
C22H20N2O4
Application Notes:
T-10418 is a potent (EC50 = 820 nM) and selective (against 300 non-olfactory GPCRs) agonist of G2 accumulation protein (G2A, GPR132). At 100 nM, T-10418 resulted in 244% TRPV1 sensitization in mouse sensory neurons. T-10418 is an interesting new chemical tool to study G2A biology.
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