Chemical Name: [(3aS,4R,6aR)-2,3,3a,5,6a-Hexahydrofuro[2,3-b]furan-4-yl] N-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate. Alternate Names: UIC-94017, TMC114
HIV-1 protease inhibitor
Molecular Weight:
547.67
Purity:
98% by HPLC NMR (conforms)
Form:
White solid
CAS Number:
[206361-99-1]
Formula:
C27H37N3O7S
Application Notes:
Darunavir is a very potent (IC50 = 3 nM against lab HIV-1 strains and clinical isolates) HIV-1 protease inhibitor that is in clinical use.1,2 Also potent against multi-PI-resistant HIV-1 strains from patient samples. Darunavir has been investigated as a potential anti-SARS-CoV2 therapeutic with mixed results.3-6
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