M606 is a cell permeable iron chelator that reduced MYCN mRNA and protein levels in BE(2)-C neuroblastoma cells as well as c-MYC protein levels in HepG2 human hepatoblastoma cells. It also significantly increased HIF1A levels in HepG2 cells independently from MYCN effects. M606 modulated glucose metabolism and inhibited TCA cycle activity in neuroblastoma cells. MYCN downregulation occurs via interaction of M606 with the activating transcription factor E2F3.
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