Olodanrigan, CAS [[1316755-16-4]]

Product Overview

• Article Name: Olodanrigan, CAS [[1316755-16-4]]
• Biozol Catalog Number: FBM-10-4957
• Supplier Catalog Number: 10-4957
• Alternative Catalog Number: FBM-10-4957-5MG, FBM-10-4957-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (S)-Benzyloxy-2-diphenylacetyl-6-methoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid. Alternate Names: EMA401

Product Description

Angiotensin II type 2 receptor antagonist

Product Properties

• Molecular Weight: 507.59
• Purity: >98% by HPLC (NMR Conforms)
• Form: Off-white solid
• CAS Number: [1316755-16-4]
• Formula: C32H29NO5

Application Notes

• Application Notes: Potent (IC50 = 39.5 nM) and selective (>10,000-fold selectivity AT2R/AT1R) antagonist of the angiotensin II type 2 receptor.1 It produced dose-dependent relief of hindpaw sensitivity in a rat model of neuropathic pain1 and showed efficacy in a human trial against postherpetic neuralgia2. Olodanrigan prevented paclitaxel-associated acute pain syndrome in mice.3 It blocked visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome.4 It was also able to inhibit proliferation of AT2R-expressing glioblastoma spheroids and blocked their invasiveness and angiogenic capability.5