Apilimod, CAS [[541550-19-0]]

Product Overview

• Article Name: Apilimod, CAS [[541550-19-0]]
• Biozol Catalog Number: FBM-10-4970
• Supplier Catalog Number: 10-4970
• Alternative Catalog Number: FBM-10-4970-5MG, FBM-10-4970-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[(E)-(3-Methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-pyridin-2-ylethoxy)pyrimidin-4-amine. Alternate Names: STA5326

Product Description

IL/12 and 23/PIKfyve inhibitor

Product Properties

• Molecular Weight: 418.50
• Purity: 99% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [541550-19-0]
• Formula: C23H26N6O2

Application Notes

• Application Notes: Potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBCs, IC50 = 1 nM in IFN-g/SAC-stimulated human PMBCs) IL-12/IL-23 inhibitor downregulating both at the transcriptional level. Suppresses Th1 but not Th2 immune response.1 Inhibition was also observed in human monocytes, monocyte-derived dendritic cells, and THP-1 cells. Apilimods mechanism of action is mediation of TLR signaling via inhibition of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve, IC50 = 14 nM).2 It displayed selective cytotoxic activity in B-cell non-Hodgkin lymphoma compared with normal cells.3 Apilimod prevented infection of VSV-ZEBOV and VSV-SARS-CoV-2 (IC50 = 50 nM) as well as SARS-CoV-2 strain 2019-nCoVB/USA-1WA/2020.4