Boceprevir, CAS [[394730-60-0]]

Product Overview

• Article Name: Boceprevir, CAS [[394730-60-0]]
• Biozol Catalog Number: FBM-10-5087
• Supplier Catalog Number: 10-5087
• Alternative Catalog Number: FBM-10-5087-5MG, FBM-10-5087-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (1R,2S,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[(2S)-2-[[[(1,1-dimethy-lethyl)amino]carbonyl]amino]-3,3-3-azabicyclo[3.1.0]hexane-2-carboxamide. Alternate Names: SCH 503034

Product Description

Antiviral, SARS-CoV-2 Mpro inhibitor

Product Properties

• Molecular Weight: 519.68
• Purity: 98% by TLC NMR (Conforms)
• Form: White or off-white solid
• CAS Number: [394730-60-0]
• Formula: C27H45N5O5

Application Notes

• Application Notes: Boceprevir (394730-60-0) directly inhibits Hepatitis C virus (HCV) NS3 protease (overall binding constant for formation of covalent adduct, Ki* = 14 nM, initial inhibition constant Ki = 7.8 µM). This blocks NS3 autoactivation, and subsequent cleavage and maturation of other viral proteins necessary for replisome assembly. This reversible, slow-binding ketoamide also restores host interferon signaling obstructed by HCV, thus reactivating the immune response1. Recently, it was also found to inhibit the key SARS-CoV-2 protease, Mpro (3CLpro) in vitro (Ki = 1.18 µM) and in cells (EC50 = 1.9 µM, virus-induced cytopathic effects (CPE)