MZ1, CAS [[1797406-69-9]]

Product Overview

• Article Name: MZ1, CAS [[1797406-69-9]]
• Biozol Catalog Number: FBM-10-5090
• Supplier Catalog Number: 10-5090
• Alternative Catalog Number: FBM-10-5090-1MG, FBM-10-5090-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (2S,4R)-1-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Product Description

BRD4 degrader

Product Properties

• Molecular Weight: 1002.64
• Purity: >98% by HPLC NMR (Conforms)
• Form: Pale-yellow solid
• CAS Number: [1797406-69-9]
• Formula: C49H60ClN9O8S2

Application Notes

• Application Notes: MZ1 consists of JQ1 tethered to a ligand for the E3 ubiquitin ligase VHL and is a selective degrader of the BET bromodomain protein BRD4. It rapidly and potently induces reversible, long-lasting and unexpectedly selective degradation of BRD4 over BRD2 and BRD3.1 It exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B.2 An important tool for studying the effects of BRD4 degradation in cancer therapy.3