Chemical Name: (R,R)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl] formamide. Alternate Names: BD 40A
beta2 adrenergic agonist
Molecular Weight:
402.5
Purity:
99% by HPLC NMR (Conforms)
Form:
White or off-white solid
CAS Number:
[43229-80-7]
Formula:
C19H24N2O4 1/2 C4H4O4
Application Notes:
Potent, long-acting agonist specific to beta2 (Ki = 7.6 nM), but not beta1 (Ki > 2.6 µM), adrenergic receptors in trachea (pD2 = 9.3) over atrium (pD2 = 7.0).1,2 Reduces adhesion and superoxide anion production in cultured activated eosinophils.3 Reverses cachexia in rats and mice via inhibition of the ATP-ubiquitin-dependent proteolytic system.4 Rescues LPS-induced motor function deficits and nigrostriatal dopamine loss in a rat model of Parkinsons.5 Clinically useful for respiratory diseases.
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