AS-1949490, CAS [[1203680-76-5]]

Product Overview

• Article Name: AS-1949490, CAS [[1203680-76-5]]
• Biozol Catalog Number: FBM-10-5103
• Supplier Catalog Number: 10-5103
• Alternative Catalog Number: FBM-10-5103-5MG,FBM-10-5103-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien

Product Description

SHIP2 inhibitor

Product Properties

• Molecular Weight: 371.88
• Purity: 98% by TLC NMR (conforms)
• Form: Off-white solid
• CAS Number: [1203680-76-5]
• Formula: C20H18ClNO2S

Application Notes

• Application Notes: A potent and selective inhibitor of the intracellular phosphatase SHIP2 (SH2 domain-containing inositol 5-phosphatase 2), IC50 = 0.62 M.1 Displays ca. 30-fold selectivity for SHIP2 over SHIP1. Activates insulin signaling via the Akt pathway in liver and lowers glucose levels in diabetic mice.1,2 Enhances BDNF expression in cultured cortical neurons.3 Ameliorates ROS generation but aggravates apoptosis in CD2AP-deficient mouse podocytes.4