A1120, CAS [[1152782-19-8]]

Product Overview

• Article Name: A1120, CAS [[1152782-19-8]]
• Biozol Catalog Number: FBM-10-5117
• Supplier Catalog Number: 10-5117
• Alternative Catalog Number: FBM-10-5117-5MG, FBM-10-5117-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

Product Description

Non-retinoid RBP4 antagonist

Product Properties

• Molecular Weight: 392.38
• Purity: >98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1152782-19-8]
• Formula: C20H19F3N2O3

Application Notes

• Application Notes: A1120 (1152782-19-8) is a high affinity (Ki = 8.3 nM) non-retinoid antagonist for RBP4 (retinol-binding protein 4), which disrupts the interaction between RBP4 and its binding partner transthyretin and lowers serum RBP4 levels in vivo in mice.1 Significantly reduces lipofuscin bisretinoid formation in the retinas of Abca4-/- mice with potential for treatment of atrophic age-related macular degeneration.2,3 Has been employed as a small molecule ''On-Switch for controlling CAR T cells in conjunction with RBP4 and engineered RBP4-binders.4