Vacuolin-1, CAS [[351986-85-1]]

Product Overview

• Article Name: Vacuolin-1, CAS [[351986-85-1]]
• Biozol Catalog Number: FBM-10-5151
• Supplier Catalog Number: 10-5151
• Alternative Catalog Number: FBM-10-5151-5MG, FBM-10-5151-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-Iodobenzaldehyde, 2-[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone

Product Description

PIKfyve inhibitor

Product Properties

• Molecular Weight: 577.43
• Purity: >98% by TLC, NMR (Conforms)
• Form: White solid
• CAS Number: [351986-85-1]
• Formula: C26H24IN7O

Application Notes

• Application Notes: Vacuolin-1 (351986-85-1) inhibits autophagy via inhibition of Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content and has no effect on other membrane-bound organelles.1 It has been shown to block endosome maturation by activating RAB5 which compromises the biogenesis and function of lysosomes including autophagosomal-lysosomal fusion and endosomal-lysosomal degradation.2 It potently inhibits migration, invasion and colony formation of cancer cells (which is linked to endosomal trafficking) and targets capping protein Zbeta (CapZbeta) in these processes.3 Inhibition of lysosomal maturation was shown to be due to potent inhibition of PIKfyve.4