C-DIM 8, CAS [[151358-47-3]]

Product Overview

• Article Name: C-DIM 8, CAS [[151358-47-3]]
• Biozol Catalog Number: FBM-10-5157
• Supplier Catalog Number: 10-5157
• Alternative Catalog Number: FBM-10-5157-5MG, FBM-10-5157-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 1,1-Bis(3-indolyl)-1-(p-hydroxyphenyl)methane. Alternate Names: DIM-C-pPhOH

Product Description

Nur77 antagonist

Product Properties

• Molecular Weight: 338.41
• Purity: 98% by TLC, NMR (Conforms)
• Form: Pink solid
• CAS Number: [151358-47-3]
• Formula: C23H18N2O

Application Notes

• Application Notes: C-DIM 8 is an antagonist of the orphan nuclear receptor Nur77 (NR4A1, TR3).1 Induces reactive oxygen species and ER stress in pancreatic cancer cells.2 C-DIM 8 mimics the effect of Nur77 knockdown in non-small-cell lung cancer A549 and H460 cells, inhibiting cell growth and inducing apoptosis which was accompanied by decreased expression of survivin and inhibition of mTORC1 signaling.3 Inhibits the expression of beta1- and beta3-integrin and blocks integrin-dependent breast cancer cell migration.4 Decreases expression of the histone methyltransferase G9A (EHMT2) in a variety of cancer cell lines.5