HET0016, CAS [[339068-25-6]]

Product Overview

• Article Name: HET0016, CAS [[339068-25-6]]
• Biozol Catalog Number: FBM-10-5246
• Supplier Catalog Number: 10-5246
• Alternative Catalog Number: FBM-10-5246-5MG, FBM-10-5246-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-Hydroxy-N-(4-butyl-2-methylphenyl)formamidine

Product Description

20-HETE biosynthesis inhibitor

Product Properties

• Molecular Weight: 206.29
• Purity: >98% by HPLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [339068-25-6]
• Formula: C12H18N2O

Application Notes

• Application Notes: HET0016 (339068-25-6) inhibits 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis via omega oxidation of arachidonic acid mediated by CYP4A and 4F (IC50=8.9 nM in human renal microsomes).1 It displays neuroprotective effects in a rat model of traumatic brain injury via inhibition of neuronal pyroptosis.2 HET0016 attenuates cerebral ischemia-reperfusion injury3 as well as oxidative injury and peripheral nerve damage in type-2 diabetic mice4. It alleviates myocardial oxidative stress5 and restores endothelial function suggesting therapeutic potential in obesity-associated vascular disease6.