ML401, CAS [[1597489-14-9]]

Product Overview

• Article Name: ML401, CAS [[1597489-14-9]]
• Biozol Catalog Number: FBM-10-5280
• Supplier Catalog Number: 10-5280
• Alternative Catalog Number: FBM-10-5280-5MG, FBM-10-5280-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (E)-3-(4-Bromophenyl)-1-(4-(4-chlorobenzyl)piperazin-1-yl)prop-2-en-1-one. Alternate Names: CID73169083, SID 173333998

Product Description

EBI2 (GPR183) antagonist

Product Properties

• Molecular Weight: 419.75
• Purity: >98% by TLC NMR (Conforms)
• Form: White solid
• CAS Number: [1597489-14-9]
• Formula: C20H20BrClN2O

Application Notes

• Application Notes: ML401 is a potent antagonist of GPR183 (IC50 = 1.03 nM), also known as EBI2 or Epstein-Barr virus-induced gene 2. ML401 inhibited 7alpha,25-dihydroxycholesterol-induced RS11846 cell chemotaxis, IC50=6 nM.1 GPR183 is a key chemotactic receptor guiding B cell localization to appropriate microenvironments for activation and differentiation.2 It also regulates the homeostasis, localization and immunological function of splenic dendritic cells.3 Oxysterols have been shown to be endogenous ligands for GPR183 with 7alpha,25-dihydroxycholesterol being the most potent (Kd=450 pM).4