Hypoxanthine is a natural purine analog and a breakdown product of adenosine.1 Together with aminopterin and thymidine, it is a component of HAT medium2, which is used to select clones during recombinant protein and antibody production, particularly important in bioprocessing. It is a biomarker of ischemia2,3, and it is used in malaria research as an essential nutrient for P. Falciparum4. It also can enable stem cell expansion.5
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