BPTES, CAS [[314045-39-1]]

Product Overview

• Article Name: BPTES, CAS [[314045-39-1]]
• Biozol Catalog Number: FBM-10-5414
• Supplier Catalog Number: 10-5414
• Alternative Catalog Number: FBM-10-5414-5MG, FBM-10-5414-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N,N-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide

Product Description

Glutaminase GLS1 inhibitor

Product Properties

• Molecular Weight: 524.68
• Purity: 98% by TLC, NMR (Conforms)
• Form: White to off-white solid
• CAS Number: [314045-39-1]
• Formula: C24H24N6O2S3

Application Notes

• Application Notes: Potent and selective allosteric1 inhibitor of kidney-type glutaminase (GLS1), IC50 = 3.3 µM2. Selective for GLS1 over GLS2, g-glutamyl transpeptidase and glutamate dehydrogenase. Shuts down an alternative energy-generating glutaminolysis pathway in P493 cells under both glucose deprivation or hypoxia.3 Reduces the growth of P493 cell xenografts by 50% over a 10 day treatment.4 BPTES inhibition of glutamine utilization in cancer cells increases PD-L1 expression.5 Clears senescent cells and improves various age-related disorders in a geriatric mouse model.6