Mito-lonidamine, CAS [[2361564-49-8]]

Product Overview

• Article Name: Mito-lonidamine, CAS [[2361564-49-8]]
• Biozol Catalog Number: FBM-10-5492
• Supplier Catalog Number: 10-5492
• Alternative Catalog Number: FBM-10-5492-5MG, FBM-10-5492-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: (10-(1,(2,4-Dichlorobenzyl)-1H-indazole-3-carboxamido)decyl)triphenylphosphonium bromide. Alternate Names: Mito-LND

Product Description

Mitochondria-targeted antiglycolytic agent

Product Properties

• Molecular Weight: 801.63
• Purity: >98% by TLC NMR (Conforms)
• Form: White solid
• CAS Number: [2361564-49-8]
• Formula: C43H45BrCl2N3OP

Application Notes

• Application Notes: Antiglycolytic drug with limited efficacy.1,2 Mito-lonidamine (2361564-49-8) is lonidamine conjugated to a triphenylphosphonium moiety via a decyl-linker which is an effective mitochondria-targeting group.3 Mito-lonidamine was shown to be100-fold more potent than lonidamine. It is a tumor-selective inhibitor of oxidative phosphorylation inhibiting mitochondrial bioenergetics in lung cancer cells and suppressing lung cancer cell viability, growth, progression and metastasis of lung cancer xenografts in mice.3