GSK4112, CAS [[1216744-19-2]]

Product Overview

• Article Name: GSK4112, CAS [[1216744-19-2]]
• Biozol Catalog Number: FBM-10-5493
• Supplier Catalog Number: 10-5493
• Alternative Catalog Number: FBM-10-5493-5MG, FBM-10-5493-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[(4-Chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]glycine, 1,1-dimethyl ester. Alternate Names: SR-6452

Product Description

Rev-Erbalpha agonist

Product Properties

• Molecular Weight: 396.89
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1216744-19-2]
• Formula: C18H21ClN2O4S

Application Notes

• Application Notes: Selective Rev-Erbalpha agonist (EC50=250 nM).1,2 It induces circadian clock phase shifts in isolated primary lung fibroblasts as well as in lung slices (10 µM).1 GSK4112 showed an inhibitory effect on the amplitude of circadian oscillations and caused an arrhythmic expression of canonical clock genes.3 In murine RAW264 macrophages it suppressed inflammatory functions via repressing Ccl2 expression.4 It protected RANKL-induced bone loss via inhibition of osteoclast differentiation in vivo.5