An azapeptide-based inhibitor of HIV protease (Ki = 2.66 nM).1 Inhibits SARS-CoV-2 main protease (Ki = 703 nM), but not papain-like protease (Ki = 9.87 µM).2 Blocks SARS-CoV-2 replication and IL-6 / TNFalpha production in vitro.3 Also inhibits the liver enzyme UDP-glucuronyltransferase 1A1 (UGT1A1), IC50 = 160 nM for recombinant UGT1A1.4
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