Calphostin C, CAS [[121263-19-2]]

Product Overview

• Article Name: Calphostin C, CAS [[121263-19-2]]
• Biozol Catalog Number: FBM-10-5635
• Supplier Catalog Number: 10-5635
• Alternative Catalog Number: FBM-10-5635-100UG, FBM-10-5635-500UG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: Fermentation product from Cladisporium cladosporioides. Alternate Names: UCN-1028C, PKF115-584

Product Description

Protein Kinase C inhibitor

Product Properties

• Molecular Weight: 790.77
• Purity: 98% by HPLC NMR (Conforms)
• Form: Dark red to light brown solid
• CAS Number: [121263-19-2]
• Formula: C44H38O14

Application Notes

• Application Notes: Potent and specific inhibitor of protein kinase C (PKC, IC50 = 50 nM).1 Inhibition of PKC is light dependent2 and is competitive with the diacylglycerol / phorbol ester binding site1. Calphostin C competes with the diacylglycerol / phorbol ester binding site in other proteins such as Munc13-1.3 Reverses oxycodone-induced tolerance to respiratory depression.4