PBMC is a potent and selective blocker of TRPM8 channels. PBMC blocks both chemical and thermal activation of TRPM8.1 Reverses the menthol and cold-induced facilitation of the micturition reflex.2 PBMC represents a new lead for analgesic drugs based on blocking TRPM8.3 Water soluble and easier to handle version of PBMC (Cat 10-1413).
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