AqB013, CAS [[1021869-51-1]]

Product Overview

• Article Name: AqB013, CAS [[1021869-51-1]]
• Biozol Catalog Number: FBM-10-5723
• Supplier Catalog Number: 10-5723
• Alternative Catalog Number: FBM-10-5723-5MG, FBM-10-5723-25MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3-(Butylamino)-4-phenoxy-N-(pyridine-4-yl)-5-sulfamoylbenzamide

Product Description

Aquaporin blocker

Product Properties

• Molecular Weight: 440.52
• Purity: >98% by TLC NMR (Conforms)
• Form: Off-white solid
• CAS Number: [1021869-51-1]
• Formula: C22H24N4O4S

Application Notes

• Application Notes: AqB013 is a selective aquaporin-1 and -4 inhibitor (IC50 ~ 20 mM) which acts at the cytoplasmic side of the AQP water pore.1 It blocks cGMP-stimulated human retinal pigment epithelium fluid transport.2 In HT29 colon cancer cells AqB013 restricted migration and invasiveness and prevented endothelial tube formation.3,4 It reduces the invasiveness of U87-MG and U251-MG glioblastoma cells in vitro.5