icFSP1, CAS [[1115910-36-5]]

Product Overview

• Article Name: icFSP1, CAS [[1115910-36-5]]
• Biozol Catalog Number: FBM-10-5735
• Supplier Catalog Number: 10-5735
• Alternative Catalog Number: FBM-10-5735-1MG, FBM-10-5735-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: 3,4,5-Trimethoxy-N-[4-(2-methyl-4-oxo-3(4H-quinazolinyl)phenyl]benzeneacetamide

Product Description

Ferroptosis suppressor protein (FSP1) inhibitor

Product Properties

• Molecular Weight: 459.50
• Purity: >96% by HPLC NMR (Conforms)
• Form: White solid
• CAS Number: [1115910-36-5]
• Formula: C26H25N3O5

Application Notes

• Application Notes: Ferroptosis suppressor protein-1 (FSP1) along with ubiquinone and NAD(P)H/H+ has been identified as a second ferroptosis suppressing system which prevents lipid peroxidation independently of the cysteine-glutathione-glutathione peroxidase 4 (GPX4) axis.1-3 icFSP1 (1115910-36-5) was discovered in a screen to identify inhibitors of FSP1. However, it does not competitively inhibit FSP1 enzyme activity but triggers subcellular relocalization of FSP1 (at 2.5 µM) from the membrane and FSP1 condensation before ferroptosis induction. icFSP1-induced FSP1 condensates show droplet-like properties consistent with phase separation. icFSP1-impairs tumor growth and induces FSP1 condensates in tumors in vivo.4