ONX-0914

Product Overview

• Article Name: ONX-0914
• Biozol Catalog Number: FBM-10-5885
• Supplier Catalog Number: 10-5885
• Alternative Catalog Number: FBM-10-5885-1MG, FBM-10-5885-5MG
• Manufacturer: Focus Biomolecules
• Category: Biochemikalien
• Alternative Names: Chemical Name: N-[2-(4-Morpholinyl)acetyl]-L-alanyl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-tyrosinamide. Alternate Names: PR-957

Product Description

Immunoproteasome inhibitor

Product Properties

• Molecular Weight: 580.68
• Purity: >98% by HPLC NMR (Conforms)
• Form: White solid
• Formula: C31H40N4O7

Application Notes

• Application Notes: ONX-0914 (960374-59-8) is a selective inhibitor of the LMP7 subunit of the immunoproteasome (IC50 = 65 nM for mouse) which is the chymotrypsin-like subunit.1 Treatment with ONX-0914 resulted in suppression of Th1 and Th17 cells but enhancement of regulatory T cell differentiation in mouse models of induced colitis.2 ONX-0914 retards rheumatoid arthritis progression3, ameliorates diabetic cardiomyopathy4 and attenuates atherosclerosis and metabolic syndrome in mice5.