The ICRF44 antibody reacts with human CD11b, also known as integrin alphaalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin alphareceptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin alphas are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin alphareceptors consist of distinct combinations of integrin alphachains which are differentially expressed. integrin alphaalpha M (CD11b) assembles with integrin alphabeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1, ICAM-2, ICAM-3 and ICAM-4 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.
Clonality:
Monoclonal
Concentration:
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
FCM: 1 µg (5 µl) for 105-108 cells in 100 µl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
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