CD8 alpha antibody [53-6.7], IgG2a, Unconjugated, Rat, Monoclonal

Product Overview

• Article Name: CD8 alpha antibody [53-6.7], IgG2a, Unconjugated, Rat, Monoclonal
• Biozol Catalog Number: GTX00604
• Supplier Catalog Number: GTX00604
• Alternative Catalog Number: GTX00604-100
• Manufacturer: GeneTex
• Host: Rat
• Category: Antikörper
• Application: Depletion, FC, ICC, IHC-Fr, IHC-P, IP
• Species Reactivity: Mouse
• Immunogen: Mouse spleen cells
• Conjugation: Unconjugated
• Alternative Names: CD8 antigen, alpha chain , BB154331 , Ly-2 , Ly-35 , Ly-B , Lyt-2

Product Description

The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

Product Properties

• Clonality: Monoclonal
• Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration.)
• Clone Designation: [53-6.7]
• Isotype: IgG2a
• NCBI: 12525
• UniProt: P01731
• Buffer: 10mM NaH2PO4, 150mM NaCl, 0.09% Sodium azide.
• Form: Liquid