CD11b antibody [M1/70], IgG2b, Unconjugated, Rat, Monoclonal

Product Overview

• Article Name: CD11b antibody [M1/70], IgG2b, Unconjugated, Rat, Monoclonal
• Biozol Catalog Number: GTX00608
• Supplier Catalog Number: GTX00608
• Alternative Catalog Number: GTX00608-100
• Manufacturer: GeneTex
• Host: Rat
• Category: Antikörper
• Application: Depletion, FC, ICC, IHC-Fr, IHC-P, IP, NeA
• Species Reactivity: Human, Mouse, Primate, Rabbit
• Immunogen: B10 mouse spleen cells enriched for T cells
• Conjugation: Unconjugated
• Alternative Names: integrin alpha M , CD11b/CD18 , CR3 , CR3A , Cd11b , F730045J24Rik , Ly-40 , MAC1 , Mac-1 , Mac-1a

Product Description

The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alphaalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin alphareceptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin alphas are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin alphareceptors consist of distinct combinations of integrin alphachains which are differentially expressed. integrin alphaalpha M (CD11b) assembles with integrin alphabeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

Product Properties

• Clonality: Monoclonal
• Concentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration.)
• Clone Designation: [M1/70]
• Isotype: IgG2b
• NCBI: 16409
• Buffer: 10mM NaH2PO4, 150mM NaCl, 0.09% Sodium azide.
• Form: Liquid